Tyrosine-Kinase and Signal Transduction
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- Reception: the ligand comes in, each monomer (unit) has a specific spot. The receptor activates and becomes a dimer (the two monomers come together)
- Transduction: dimerization activated the tyrosine kinase region of each monomer so each tyrosine-kinase adds a phosphate (taken from an ATP molecule) to a tyrosine on the other monomer. The receptor is now fully activated
- Response: the fully activated receptor is recognized by relay proteins which bind specifically to each tyrosine. These proteins are activated and each protein triggers its own transduction pathway which leads to a cellular response